Natural and Effective Remedies
The fruit and juice are typically gathered for eliminating worms and unwanted organisms, cooling high fevers, and as an astringent for dysentery as well as diarrhea . The fruit, bark, roots, leaves, and even the seeds of the Soursop Tree can be made use of for organic remedies.
Oftentimes the crushed plant seeds are made use of for opposition to external and internal parasitic organisms, worms, and lice. The leaves, roots, and bark can be crushed and used in herbal tea as a sedative.
Various regions thave used Soursop to assist in the remedy for a number of health conditions. Throughout the Peruvian Andes, the leaves are often made use of in tea to treat the swelling of mucous membranes, while the plant seeds are used in the elimination of parasitic organisms.
The people of the Peruvian Amazon use the leaves, bark, and seeds to produce a tea as a remedy towards the treatment of diabetes. The natives of the Brazilian Amazon use a leaf herbal tea for liver difficulties and the oil from the leaves along with the fruit can be combined collectively and used for arthritis.
The people of the West Indies, Jamaica and Haiti, use the bark as a sedative and the fruit is utilized to lessen coughs, flu virus, and symptoms of asthma, high blood pressure levels, in addition to parasitic organisms.
Tribal and Herbal Medicine Applications
Amazon Tribal PeopleEach aspect of the Soursop tree is used throughout natural medicine within the tropics,including the bark, leaves, roots, fruit, as well as fruit seeds. Numerous uses are ascribed to the various areas of the tree.
Overall, the fruit along with fruit juice are taken for worms and parasites, to reduce high fevers, to enhance mother’s milk following childbirth, as well as used an astringent with regard to diarrhea and dysentery. The smashed seeds are made use of in opposition to inner and outer parasitic organisms, head lice, as well as worms.
The bark, leaves, and roots are taken as a sedative, antispasmodic, hypotensive, and nervine, and a tea is created for many other ailments. Soursop includes an extensive, vibrant reputation of use within organic medication as well as to a prolonged documented indigenous use.
The people of the Peruvian Andes use a leaf tea for catarrh (irritation of mucous membranes) and the crushed seed is utilized to rid the body of parasitic organisms. Within the Peruvian Amazon the bark, roots, along with the leaves are made use of for diabetic conditions and as a sedative and antispasmodic.
Native tribes within Guyana make use of the leaf and/or bark tea as a sedative and heart tonic. The people of the Brazilian Amazon use a leaf tea for liver conditions, and the oil of the leaves and unripe fruit is mixed with olive oil and utilized externally for neuralgia, rheumatism, and arthritis pain. The natives of Jamaica, Haiti, as well as the West Indies, use the fruit and/or fruit juice for fevers, parasites and diarrhea; the bark or leaf is effective as an antispasmodic, sedative, and nervine for heart ailments, flu, coughs, difficult childbirth, asthma, high blood pressure, and parasites.
Plant Elements and Scientific Research
There have been many active chemicals that have been identified within Soursop, as scientists have been researching its qualities since the 1940s. Most of the investigation on Soursop focuses on a novel group of chemical substances identified as Annonaceous acetogenins. Soursop produces these natural chemicals within its leaf and stem, bark, and fruit seeds.
Guyabuno, Also Known As Guanabana
3 independent research studies have proven that these chemical substances have substantial anti-tumorous elements and targeted toxicity in opposition to various forms of cancer cells, without harming healthy cells, releasing eight scientific studies on their findings. Most of the acetogenins have displayed discerning toxicity to tumor cells at shocking low dosages-as small as 1 part per million.
4 examinations had been published in 1998, which further show the chemical substances and acetogenins within graviola, which are displaying the strongest anticancerous, antitumorous, and antiviral elements. In a 1997 medical analysis, novel alkaloids located within Soursop fruit displayed anti-depressive outcomes within animals.
Annonaceous acetogenins are exclusively identified within the Annonaceae family (to which Soursop is part of). These chemical elements typically have been recorded with anti-tumorous, anti-parasitic, insecticidal, and anti-microbial activities. 3 independent laboratories recently established that these acetogenins are amazing inhibitors of enzyme procedures, which are exclusively located inside the membranes of cancerous tumor cells.
It is because of this, they are toxic to cancer cells, yet have no toxicity to the healthy cells. Purdue University, in West Lafayette, Indiana, has performed substantial quantities of research on the acetogenins, most of which, has been backed financially by The National Cancer Institute and/or the National Institute of Health (NIH). To this day, Purdue University and/or its staff have entered at least 9 U.S. and/or international patents on their work around the anti-tumorous and insecticidal elements and uses of these acetogenins.
Purdue University released studies in 1997 with hopeful information that many of the Annonaceous acetogenins were not only are successful in ridding tumors that were confirmed resistant towards anti-cancer agents, but furthermore appear to have a distinct affinity for such resistant cells. Many interviews after this information was published, the head pharmacologist in Purdue’s analysis noted precisely how this worked.
As he describes it, cancer cells which survive chemotherapy can create a level of resistance to the agent previously used in addition to other, even unrelated, medication. This happening is referred to as as multi-drug resistance (MDR). One of the major methods that cancer cells develop opposition to chemotherapy drugs is through creating an inter-cellular pump, which is capable at pushing anti-cancer agents out of the cell prior to killing it. Generally, only about 2 % of the cancer cells in any given person may create this pump, yet those are the 2 % that can ultimately grow and expand to generate multi-drug-resistant tumors.
A majority of the most current experimentations upon acetogenins claimed that they were able to shut down these intercellular pumps, therefore eliminating multi-drug-resistant tumors. Purdue researchers documented that the acetogenins preferentially eliminated multi-drug-resistant cancer cells by blocking the transfer of ATP, which is the main source of cellular energy.
Inside the Fruit
A tumor cell calls for energy to expand and replicate, and a great deal more to operate its pump and rid itself of attacking agents. By limiting energy to the cell , it can no longer run its pump. At the moment the acetogenins block ATP towards the tumor cell over time, the cell will no longer have adequate energy to perform preserving actions and it perishes.
Normal, healthy cells rarely develop this form of pump; consequently, they do not call for substantial amounts of energy to operate a pump and, typically, are not negatively affected by ATP inhibitors. Purdue researchers noted that fourteen various acetogenins examined to date display effective ATP blocking attributes (which includes a number of which which had been discovered exclusively within graviola).
Furthermore, they documented that 13 of these 14 acetogenins analyzed were more efficient in opposition to MDR breast cancer cells than the 3 typical medications (adriamycin, vincristine, and vinblastine) they used as controls. The Annonaceous acetogenins recognized within Soursop so far contain: annocatalin, annohexocin, annomonicin, annomontacin, annomuricatin A & B, annomuricin A thru E, annomutacin, annonacin, annonacinone, annopentocin A thru C, cis-annonacin, cis-corossolone, cohibin A thru D, corepoxylone, coronin, corossolin, corossolone, donhexocin, epomuricenin A & B, gigantetrocin, gigantetrocin A & B, gigantetrocinone, gigantetronenin, goniothalamicin, iso-annonacin, javoricin, montanacin, montecristin, muracin A thru G, muricapentocin, muricatalicin, muricatalin, muri-catenol, muricatetrocin A & B muricatin D, muricatocin A thru C muricin H, muricin I, muricoreacin, murihexocin 3, murihexocin A thru C, murihexol, murisolin, robustocin, rolliniastatin 1 & 2, saba-delin, solamin, uvariamicin I & IV, xylomaticin
Biological Activites and Clinical Studies
Soursop leaves along with the stem demonstrated active toxicity in opposition to cancer cells according to an investigation within a plant screening program in the mid 70’s by the National Cancer Institute. Researchers have been following up on these discoveries ever since.
To this day, specific acetogenins within Soursop and/or extracts of Soursop have been noted to be distinctly toxic in vitro to the following tumor cells: lung carcinoma cell lines; human breast solid tumor lines; prostate adenocarcinoma; pancreatic carcinoma cell lines; colon adenocarcinoma cell lines; liver cancer cell lines; human lymphoma cell lines; and multi-drug resistant human breast adenocarcinoma.
In 2003, scientists in Taiwan documented that the principle Soursop acetogenin, annonacin, was very toxic to ovarian, cervical, breast, bladder as well as skin cancer cell lines at surprisingly minimal dosages, making annonacin as an encouraging anti-cancer agent and meriting further animal experiments as well as clinical trials.
In March of 2002, an astounding in vivo study had been released by scientists in Japan, who have been researching various acetogenins present in a variety of species of plants. They inoculated mice with lung cancer cells. One third had been given nothing (the control group), one third had been given the chemotherapy drug adriamycin, and finally, one third were given the primary Soursop acetogenin, annonacin (at a dosage of 10 mg/kg).
In Vivo Study
Following the end of 2 weeks, 5 of the 6 in the untreated control group remained as alive and lung tumor sizes were then assessed. The adriamycin group displayed a 54.6% decrease in tumor mass over the control group, however 50% of the animals passed away from poisoning (3 of 6).
The mice that had received annonacin were all still alive, and the tumors had been limited by 57.9%, somewhat better than adriamycin and without toxicity. This led the scientists to document; “This suggested that annonacin was less toxic in mice. Upon considering the antitumor activity and toxicity, annonacin might be utilized as a lead to develop a promising anticancer agent.”
Modern Practical Uses
Cancer analysis is ongoing regarding these essential Annona plants and plant chemicals, as many of pharmaceutical drug companies and universities continue to study, analyze, patent, and attempt to synthesize these chemical compounds into new chemotherapeutic medicines.
In fact, Soursop appears to be adhering to the similar path as yet another well-known cancer medication – Taxol. From the very instance researchers first identified an antitumorous result within the bark of the pacific yew tree and a novel chemical recognized as taxol was identified in its
bark – it took 30 years of research by a number of pharmaceutical drug companies, universities, and government agencies prior to the first FDA-approved Taxol drug was allowed to be sold to a cancer patient (which was dependent on the natural taxol chemical they discovered in the tree bark).
With Soursop, it has taken researchers around ten years to effectively chemically replicate, or synthesize the primary antitumorous chemical, annonacin. These acetogenin chemicals have a unique waxy center and additional unique molecular energy attributes, which thwarted efforts in the past, and at least one major pharmaceutical drug company gave up during this process (regardless of comprehending how active the natural chemical was in opposition to cancers).
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